個人簡介

何啟蓋，男，博士，教授，博士生導師。2002.11-2006.3：在新加坡國立大學做訪問學者和博士後研究。入選教育部新世紀優秀人才（2006）, 是國家生豬産業技術體系疾病控制崗位科學家（2017），農業部規模化養殖場疫病淨化評估認證專家，國家生豬産業技術創新戰略聯盟副理事長，亞洲豬病學會國家理事。主要開展豬僞狂犬病、豬圓環病毒病、豬流行性腹瀉、副豬嗜血杆菌病、傳染性胸膜肺炎等疾病的病原分離、緻病機理、新型疫苗、診斷制劑與綜合防控措施研究。“12.5”和“13.5”期間，承擔了國家自然科學基金、國家重點研發計劃、國家生豬産業技術體系項目、農業部公益性行業科技專項等課題。在EID、Journal of Virology、Virology、畜牧獸醫學報等國内外重要學術刊物發表70多篇研究文章，獲得3項新獸藥注冊證書和8項發明專利。獲3項國家級、省部級獎勵。常年服務國内外養豬企業的疾病防控與淨化。已培養畢業近80名國内外研究生，注重培養學生學以緻用，解決臨床實際問題。

教育經曆

1984.09 - 1989.06，西南民族大學，獸醫專業畢業，醫學學士
1990.09 - 1993.06，四川農業大學，傳染病學與預防獸醫學專業畢業，農學碩士
1996.09-2000.06，yl7703永利，動物遺傳育種與繁殖（抗病方向），農學博士

工作經曆

1993.06-2002.11，yl7703永利助教、講師，副教授，碩士生導師。
2002.11-2006.03，新加坡國立大學訪問學者和博士後
2006.04-現在，yl7703永利教授，碩士和博士生導師

研究領域

豬傳染病臨床診斷和控制、緻病機制、新型疫苗與診斷制劑。

科研成果

A著作類
1. 主編之一，《僞狂犬病》，中國農業出版社，2015
2. 副主編，《獸醫手冊》（中國農業出版社）和《中國生豬産業技術進展》（湖南科學技術出版社）；副主譯《生物安全選集XI》（中國農業出版社）。
3.參編（譯），《默克獸醫手冊》（中國農業出版社）、《人獸共患病學》（四川科學技術出版社）
B論文類
Yang W, Pin C, Haibing G, Yang C, Hui L, Qigai H. Loop-mediated isothermal amplification targeting the apxIVA gene for detection of Actinobacillus pleuropneumoniae. FEMS Microbiol Lett. 2009 Nov; 300(1):83-9.
Yang W, Pin C, Haibing G, Yang C, Hui L, Qigai H. Loop-mediated isothermal amplification targeting the apxIVA gene for detection of Actinobacillus pleuropneumoniae.; FEMS Microbiol Lett. 2009 Nov; 300(1):83-9
Wang Yang, Fang Ying, Liu Yingyu, Chen Pin, Li Wentao, Liu Shuqing, Zou Haoyong, He Qigai. Development and evaluation of loop-mediated isothermal amplification for rapid detection of Haemophilus parasuis. FEMS Microbiology Letters, 2010, 313(1):54-60
Huimin Zhang, Wentao Li, Zonghai Sheng, Heyou Han and Qigai He. Ultrasensitive detection of porcine circovirus type 2 using gold (III) enhanced chemiluminescence immunoassay. Analyst, 2010,135(7):1680-1685
Chen H, Cheng L, Yang S, Liu X, Liu Y, Tang J, Li X, He Q, Zhao S. Molecular characterization, induced expression, and transcriptional regulation of porcine S100A12 gene. Mol Immunol. 2010 Apr; 47(7-8):1601-7.
Pin Chen，Yingyu Liu，Chong Liu，Haoyong Zou，Yang Wang，Wentao Li，Dingren Bi and Qigai He. Laboratory Detection of Haemophilus parasuis with Decreased Susceptibility to Nalidixic Acid and Enrofloxacin Due to GyrA and ParC Mutations. Journal of Animal and Veterinary Advances. 2011, 10(21):2870-2873
Hao-Yong Zou, Xin-Jun Liu, Feng-Ying Ma, Pin Chen, Rui Zhou, Qi-Gai He. Attenuated Actinobacillus pleuropneumoniae as a bacterial vector for expression of Mycoplasma hyopneumoniae P36 gene. The Journal of Gene Medicine. 2011, 13(4):221-229
Zhao Z, Wang C, Xue Y, Tang X, Wu B, Cheng X, He Q, Chen H. The occurrence of Bordetella bronchiseptica in pigs with clinical respiratory disease.Vet J. 2011 Jun; 188(3):337-40.
Wang Y, Liu C, Fang Y, Liu X, Li W, Liu S, Liu Y, Liu Y, Charreyre C, Audonnet JC, Chen P, He Q. Transcription analysis on response of porcine alveolar macrophages to Haemophilus parasuis. BMC Genomics. 2012 Feb 13;13:68
Cheng S, Zhang M, Li W, Wang Y, Liu Y, He Q; Proteomic analysis of porcine alveolar macrophages infected with porcine circovirus type 2; J Proteomics. 2012 Jun 18;75(11):3258-69
Yingyu Liu, Pin Chen, Yang Wang, Wentao Li, Shuang Cheng, Chunmei Wang, Anding Zhang, Qigai He;Transcriptional profiling of Haemophilus parasuis SH0165 response to tilmicosin. Microbial Drug Resist. 2012 Dec;18(6):604-15
Liu C, Wang Y, Zhang H, Cheng S, Charreyre C, Audonnet JC, Chen P, He Q. Porcine coronin 1A contributes to nuclear factor-kappa B (NF-κB) inactivation during Haemophilus parasuis infection. PLoS One. 2014 Aug 5; 9(8):e103904.
Hu H, Wang C, Guo X, Li W, Wang Y, He Q. Broad activity against porcine bacterial pathogens displayed by two insect antimicrobial peptides moricin and cecropin B. Mol Cells. 2013 Feb; 35(2):106-14
Li W, Liu S, Wang Y, Deng F, Yan W, Yang K, Chen H, He Q, Charreyre C, Audoneet JC. Transcription analysis of the porcine alveolar macrophage response to porcine circovirus type 2. BMC Genomics. 2013 May 27; 14:35310.
Cheng S, Yan W, Gu W, He Q. The ubiquitin-proteasome system is required for early stages of porcine circovirus type 2 replication. Virology. 2014 May; 456-457:198-204.
Chen F, Hu H, Li Z, Huang J, Cai X, Wang C, et al. Deletion of HAPS_2096 Increases Sensitivity to Cecropin B in Haemophilus parasuis. J Mol Microbiol Biotechnol 2015;25:284-91.
Chen F, Zhu Y, Wu M, Ku X, Yao L, He Q. Full-Length Genome Characterization of Chinese Porcine Deltacoronavirus Strain CH/SXD1/2015. Genome Announc 2015;3.
Chen F, Zhu Y, Wu M, Ku X, Ye S, Li Z, et al. Comparative Genomic Analysis of Classical and Variant Virulent Parental/Attenuated Strains of Porcine Epidemic Diarrhea Virus. Viruses 2015;7:5525-38.
Guo X, Hu H, Chen F, Li Z, Ye S, Cheng S, et al. iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus. J Proteomics 2016;130:65-75.
Li W, Wicht O, van Kuppeveld FJ, He Q, Rottier PJ, Bosch BJ. A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion. J Virol 2015;89:8077-81.
Ye S, Li Z, Chen F, Li W, Guo X, Hu H, et al. Porcine epidemic diarrhea virus ORF3 gene prolongs S-phase, facilitates formation of vesicles and promotes the proliferation of attenuated PEDV. Virus Genes 2015;51:385-92.
Ye S, Shao K, Li Z, Guo N, Zuo Y, Li Q, et al. Antiviral Activity of Graphene Oxide: How Sharp Edged Structure and Charge Matter. ACS Appl Mater Interfaces 2015;7:21571-9.
Li, Z., Chen, F., Ye, S., Guo, X., Muhanmmad Memon, A., Wu, M. & He, Q. (2016). Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated Strain. Viruses 8, 323.
Chen, F., Ku, X., Li, Z. & other authors (2016). Genetic characteristics of porcine epidemic diarrhea virus in Chinese mainland, revealing genetic markers of classical and variant virulent parental/attenuated strains. Gene 588, 95-102.
Deng, F., Ye, G., Liu, Q. & other authors (2016). Identification and comparison of receptor binding characteristics of the spike protein of two porcine epidemic diarrhea virus strains. Viruses 8, 55.
Guo, X., Hu, H., Chen, F., Li, Z., Ye, S., Cheng, S., Zhang, M. & He, Q. (2016). iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus. Journal of proteomics 130, 65-75.Li, W., van Kuppeveld, F. J., He, Q., Rottier, P. J. & Bosch, B.-J. (2016). Cellular entry of the porcine epidemic diarrhea virus. Virus research 226, 117-127.
Guo, X., Zhang, M., Zhang, X. & other authors (2017). Porcine Epidemic Diarrhea Virus Induces Autophagy to Benefit Its Replication. Viruses 9, 53.
Li, W., Luo, R., He, Q., van Kuppeveld, F. J., Rottier, P. J. & Bosch, B.-J. (2017). Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry. Virus research 235, 6-13.
Memon AM, Bhuyan AA, Chen F, Guo X, Menghwar H, Zhu Y, Ku X, Chen S, Li Z, He Q. (2017). Development and Validation of Monoclonal Antibody-Based Antigen Capture ELISA for Detection of Group A Porcine Rotavirus.Viral Immunol. 30(4):264-270.
Lei Z, Liu Q, Yang B, Ahmed S, Xiong J, Song T, Chen P, Cao J, He Q.(2017).Evaluation of Bioequivalence of Two Long-Acting 20% Oxytetracycline Formulations in Pigs.Front Vet Sci. May 1;4:61.
Lei Z, Liu Q, Yang B, Xiong J, Li K, Ahmed S, Hong L, Chen P, He Q, Cao J.(2017). Clinical Efficacy and Residue Depletion of 10% Enrofloxacin Enteric-Coated Granules in Pigs.Front Pharmacol.23;8:294.

科研項目

國家生豬産業技術體系項目（CARS-36，CARS-35），重點開展豬瘟僞狂犬病淨化、豬藍耳病和常見細菌病的綜合防控；
國家重點研發專項-豬重要疫病抗體快速檢測技術研究（2016YFD0500702）（重點開展豬流行性腹瀉sIgA-ELISA試劑盒研制）
武漢市國際合作課題-豬流行性腹瀉新型疫苗和鑒别診斷方法研究和企業合作課題。
企業合作課題多項：涉及新型疫苗和診斷試劑開發；豬場疾病淨化與控制。

主要獎勵

1. 2012年參與獲得國家科技進步一等獎（排名第5）,
2. 2016年獲得國家科技進步二等獎（排名第3）
3.以第一完成人獲得新獸藥注冊證書2項