個人簡介

彭貴青，男，江西貴溪人。yl7703永利教授、博士生導師，院長助理，農業微生物學國家重點實驗室固定人員。國家“萬人計劃”青年拔尖人才、教育部青年長江學者、國家自然科學基金“優青”獲得者（2017）。華中農業大農學學士、武漢大學微生物學博士。長期專注于冠狀病毒研究，圍繞該病毒入侵、複制的分子機制，取得一系列具有國際影響的創新性研究成果。先後解析冠狀病毒(MHV、BcoV)刺突蛋白結構、病毒受體(CEACAM1b、PAPN)的結構，以及刺突蛋白與受體複合物（MHV刺突蛋白與受體CEACAM複合物、SARS-CoV刺突蛋白與受體ACE2複合物）的結構；首次發現冠狀病毒刺突蛋白具有凝集素樣結構，闡明了冠狀病毒識别糖受體的分子機理；并且揭示了冠狀病毒與受體共進化的機制。首次解析了動脈炎病毒科PRRSV核酸内切酶NSP11的結構，發現了與冠狀病毒核酸内切酶完全不同的聚合方式，闡明了核酸内切酶參與病毒複制的新機制。承擔有國家自然科學基金、中組部拔尖人才基金、973子課題等科研項目。曾獲第十三屆湖北省自然科學優秀學術論文一等獎，第七屆國際病毒學會Christophe Meriux 獎。近五年以第一作者或通訊作者在PNAS、Journal of Biological Chemistry 、Journal of Virology、Scientific Report等雜志發表系列研究論文。現為湖北省晶體學會理事，Journal of Virology、Virology、JGV等雜志審稿人。

教育經曆

1997.09 - 2001.06， yl7703永利，獸醫專業畢業，學士學位
2001.09 - 2004.06， yl7703永利，預防獸醫學畢業，碩士學位
2004.09 - 2007.06，武漢大學，微生物學專業畢業，理學博士學位

工作經曆

2007.11-2008.10，中國科學院武漢病毒學研究所助理研究員
2009.01-2012.07，美國明尼蘇達大學藥學院博士後
2012.08- 至今，yl7703永利“楚天學者特聘教授”（2012），博士生導師，農業微生物學國家重點實驗室固定人員

研究領域

從事分子病毒學及蛋白質結構生物學研究，研究方向包括重要病原體入侵及其與宿主相互作用的分子機理；病原體耐藥分子機理；新型抗病毒藥物和診斷方法的開發與研制。

科研成果

2011年以來發表的文章：
1. Shen Z, Ye G, Deng F, Wang G, Cui M, Fang L, Xiao S, Fu ZF, Peng G*.Structural basis for the inhibition of host gene expression by porcine epidemic diarrhea virus nsp1. J Virol.（in press）
2. Shi Y, Lei Y, Ye G, Sun L, Fang L, Xiao S, Fu ZF, Yin P, Song Y*, Peng G*. Identification of Two Antiviral Inhibitors Targeting 3C-like Serine/3C-like Protease of Porcine Reproductive and Respiratory Syndrome Virus and Porcine Epidemic Diarrhea Virus. Veterinary Microbiology. Volume 213, January 2018, Pages 114–122
3. Zeng Z, Li TT, Jin X, Peng FH, Song NH, Peng GQ*, Ge XY*. Coexistence of multiple genotypes of porcine epidemic diarrhea virus with novel mutant S genes in the Hubei Province of China in 2016. Virol Sin. 2017 Aug;32(4):298-306.
4. Zhu X, Wang D, Zhou J, Pan T, Chen J, Yang Y, Lv M, Ye X, Peng G, Fang L, Xiao S. Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2. J Virol. 2017 Apr 28;91(10). pii: e00003-17.
5. Peng G, Yang Y, Pasquarella JR, Xu L, Qian Z, Holmes KV, Li F.Structural and Molecular Evidence Suggesting Coronavirus-driven Evolution of Mouse Receptor. J Biol Chem. 2017 Feb 10;292(6):2174-2181.
6. Fang J, Li H, Kong D, Cao S, Peng G, Zhou R, Chen H, Song Y.Structure-based discovery of two antiviral inhibitors targeting the NS3 helicase of Japanese encephalitis virus. Sci Rep. 2016 Sep 29;6:34550.
7. Ye G, Deng F, Shen Z, Luo R, Zhao L, Xiao S, Fu ZF, Peng G*. Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease. Virology. 2016 Jul;494:225-35.
8. Shi Y, Li Y, Lei Y, Ye G, Shen Z, Sun L, Luo R, Wang D, Fu ZF, Xiao S, Peng G*. A Dimerization-Dependent Mechanism Drives the Endoribonuclease Function of PRRSV nsp11. J Virol. 2016 Feb 24. pii: JVI.03065-15.
9. Wang J, Deng F, Ye G, Dong W, Zheng A, He Q, Peng G*. Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses. Virol Sin. 2016 Feb;31(1):49-56.
10. Deng F, Ye G, Liu Q, Navid MT, Zhong X, Li Y, Wan C, Xiao S, He Q*, Fu ZF*, Peng G*. Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains. Viruses. 2016 Feb 23;8(3). pii: E55.
11. Sui B, Huang J, Jha BK, Yin P, Zhou M, Fu ZF, Silverman RH, Weiss SR, Peng G*, Zhao L*. Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation. J Gen Virol. 2016 Jan 12.
12. Li Y, Dong W, Shi Y, Deng F, Chen X, Wan C, Zhou M, Zhao L, Fu ZF*, Peng G*. Rabies virus phosphoprotein interacts with ribosomal protein L9 and affects rabies virus replication. Virology. 2016 Jan 15;488:216-24.
13. Wang D，Fang L，Shi Y，Zhang H，Gao L，Peng G，Chen H，Li K，Xiao S.Porcine Epidemic Diarrhea Virus 3C-Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO，J Virol. 2015，90（4）：2090-2101.
14. Dong W, Huang J, Li Y, Tan Y, Shen Z, Song Y, Wang D, Xiao S, Chen H, Fu ZF*, Peng G*. Crystal structural basis for Rv0315, an immunostimulatory antigen and inactive beta-1,3-glucanase of Mycobacterium tuberculosis. Sci Rep. 2015 Oct 15;5:15073. 15. Liu C，Tang J，Ma Y，Liang X，Yang Y，Peng G，Qi Q，Jiang S，Li J，Du, L，Li F. Receptor usage and cell entry of porcine epidemic diarrhea coronavirus，J Virol. 2015，89（11）：6121-6125.
16. Zhang Y, Li H, Peng G, Zhang Y, Gao X, Xiao S, Cao S, Chen H, Song Y.Mutational analysis of the functional sites in porcine reproductive and respiratory syndrome virus non-structural protein 10.J Gen Virol. 2015 Mar;96(Pt 3):547-52. doi: 10.1099/jgv.0.000004. Epub 2014 Dec 5.
17. Zhang H, Li X, Peng G, Tang C, Zhu S, Qian S, Xu J, Qian P.Glycoprotein E2 of classical swine fever virus expressed by baculovirus induces the protective immune responses in rabbits.Vaccine. 2014 Nov 20;32(49):6607-13.
18. Fang J, Sun L, Peng G, Xu J, Zhou R, Cao S, Chen H, Song Y.Identification of three antiviral inhibitors against Japanese encephalitis virus from library of pharmacologically active compounds 1280.PLoS One. 2013 Nov 4;8(11):e78425.
19. Fang J, Li H, Peng G, Cao S, Zhen FF, Chen H, Song Y.Methods for detecting ATP hydrolysis and nucleic acid unwinding of Japanese encephalitis virus NS3 helicase.J Virol Methods. 2013 Dec;194(1-2):33-8.
20. Peng G, Xu L, Chen L, Lin YL, Chen L, Pasquarella JR, Holmes KV, Li F. Crystal structure of bovine coronavirus spike protein lectin domain. J Biol Chem. 2012. Dec 7;287(50):41931-8.
21. Chen L, Lin YL, Peng G, Li F. Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc Natl AcadSci U S A. 2012 Oct 30;109(44):17966-71.
22. Wu K#, Peng G# (Co-first author), Wilken M#, Geraghty RJ, Li F. Mechanism of Host Receptor Adaptation by SARS Coronavirus. J Biol Chem. 2012 ;287(12):8904-11.
23. Peng G, Sun D, Rajashankar K, Qian Z, Holmes K, Li F. Structure of mouse coronavirus galectin-likedomain complexed with its protein receptor. Proc Natl AcadSci U S A. 2011 Jun 16, 108, 10696-10701.
24. Wu K, Chen L, Peng G, Zhou W, Pennell CA, Mansky LM, Geraghty RJ, Li F.A Virus-binding Hotspot on Human Angiotensin-converting Enzyme 2 is Critical for the Binding of Two Different Coronaviruses. J Virol. 2011 Mar; 85, 5331-5337.

科研項目

1. 國家自然科學基金優青(No.31722056) 2018-2020
2. 國家自然科學基金面上(No.31372440)2014-2017
3. 中組部青年拔尖人才2015-2018
4. 973項目 (2014CB542700) 骨幹2014-2018
5. 湖北省自然科學基金重點項目2017-2019
6. 教育部新教師基金(No.4010-131011)2013-2015
7. 湖北省基金面上（No.4006-36113009)2013-2015
8. 創新群體研究骨幹2014-2018
9. 微生物國家重點實驗室2012-2017
10. 楚天學者特聘教授啟動基金2012-2017
11. 校傑青培植基金2015-2017
12. 自主科技創新基金(No.2013PY031）2013-2015

主要獎勵

1. 第十三屆湖北省自然科學優秀學術論文一等獎。
2. 第七屆國際病毒學會Christophe Meriux獎。
3.國家“萬人計劃”青年拔尖人才。
4.教育部青年長江學者。
5. 國家自然科學基金“優青”獲得者。
6. 科技部中青年領軍人才