個人簡介

肖少波，1969年出生，博士，yl7703永利二級崗教授、博士生導師，國家傑出青年基金獲得者(2012)、教育部“長江學者”特聘教授、湖北省自然科學基金創新研究群體學術帶頭人。先後入選國家農業科研傑出人才、國家中青年科技創新領軍人才（2013）、國家百千萬人才工程（2013）、教育部新世紀優秀人才（2007）、武漢市黃鶴科技英才等人才計劃，榮獲“國家有突出貢獻中青年專家”（2013）等榮譽稱号，享受國務院政府特殊津貼。兼任中國免疫學會獸醫免疫學專業委員會委員、湖北省微生物學會畜牧獸醫微生物學專業委員會主任，《病毒學報》、《中國動物傳染病學報》等雜志編委。主要開展豬繁殖與呼吸綜合征病毒、豬腸道冠狀病毒等重要動物病毒的病原學與流行病學、病毒與宿主免疫系統的相互作用、新型疫苗與診斷技術研究。先後承擔國家自然科學基金重大項目、國家傑出青年基金、973計劃、863計劃、國家科技支撐計劃、教育部科學技術研究重大項目等科研課題，在Journal of Virology (JVI)、Journal of Biological Chemistry (JBC)、Journal of Proteome Research (JPR) 等國際期刊上發表SCI論文130餘篇，申報/獲得國家發明專利20餘項，新獸藥注冊證書2項。

教育經曆

2001/09 – 2004/06，yl7703永利，yl7703永利，博士
1997/09 – 2000/12，yl7703永利，yl7703永利，碩士
1988/09 – 1992/06，yl7703永利，畜牧獸醫學院，本科

工作經曆

2011/01 – 至今， yl7703永利，yl7703永利，教授
2011/06 – 2011/07，美國佐治亞大學，獸醫學院，訪問學者
2006/07 – 2010/12，yl7703永利，yl7703永利，副教授
2004/11 – 2005/04，德國哥廷根大學，獸醫研究所，訪問學者
2004/07 – 2006/06，yl7703永利，yl7703永利，講師
1992/07 – 1997/08，湖北省沙市農場，技術員

研究領域

1. 病原學與流行病學
2. 病毒與宿主免疫系統相互作用
3. 新型疫苗與診斷試劑創制

科研成果

1.Xiao S, Chen H, Fang L, Liu C, Zhang H, Jiang Y, Hong W. Comparaison of immune resp[onses and protective efficacy of suicidal DNA vaccine and conventional DNA vaccine encoding glycoprotein C of pseudorabies virus in mice. Vaccine. 2004, 22(3-4):345-351.
2.Jiang Y, Xiao S, Fang L, Yu X, Song Y, Niu C, Chen H. DNA vaccines co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus (PRRSV) display enhanced immunogenicity. Vaccine. 2006, 24(15):2869-2879.
3.Fang L, Jiang Y, Xiao S, Niu C, Zhang H, Chen H. Enhanced immunogenicity of the modified GP5 of porcine reproductive and respiratory syndrome virus. Virus Genes. 2006, 32(1):5-11.
4.Yu X, Xiao S, Fang L, Jiang Y, Chen H. Enhanced immunogenicity to food-and-mouth disease virus in mice vaccination with alphaviral replicon-based DNA vaccine expressing the capsid precursor polypeptide (P1). Virus Genes. 2006, 33(3):337-344.
5.Xiong F, Xiao S, YU, Li W, Zheng H, Shang Y, Peng F, Zhao C, Zhou W, Chen H, Fang L, Zhang C. Enhanced effect of microdystrophin gene transfection by HSV-VP22 mediated intercellular protein transport. BMC Neurosci. 2007, 8:50.
6.Xiong F, Xiao S, Peng F, Yu M, Yuan Y, Chen H, Fang L, Zhang C. HSV-VP22 enhances adenovirus-mediated microdystrophin gene transfer to skeletal muscles in dystrophin-deficient (mdx) mice. Hum Gene Ther. 2007, 18(6):490-501.
7.Jiang Y, Fang L, Xiao S, Zhang H, Pan Y, Luo R, Li B, Chen H. Immunogenicity and protective efficacy of recombinant pseudorabies virus expressing the two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus. Vaccine. 2007, 25(3):547-560.
8.Wang S, Fang L, Fan H, Jiang Y, Pan Y, Luo R, Zhao Q, Chen H, Xiao S. Construction and immunogenicity of pseudotype baculovirus expressing GP5 and M protein of porcine reproductive and respiratory syndrome virus. Vaccine. 2007, 25(49):8220-8227.
9.Wang D, Fang L, Li T, Luo R, Xie L, Jiang Y, Chen H, Xiao S. Molecular cloning and functional characterization of porcine IFN-β promoter stimulator 1 (IPS-1). Vet Immunol Immunopathol. 2008, 125(3-4):344-353.
10.Fan H, Pan Y, Fang L, Wang D, Wang S, Jiang Y, Chen H, Xiao S. Construction and immunogenicity of recombinant pseudotype baculovirus expressing the capsid protein of porcine circovirus type 2 in mice. J Virol Methods. 2008, 150(1-2):21-26.
11.Fan H, Xiao S, Tong T, Wang S, Xie L, Jiang Y, Chen H, Fang L. Immunogenicity of porcine circovirus type 2 capsid protein targeting to different subcellular compartments. Mol Immunol. 2008, 45(3):653-660.
12.Luo R, Xiao S, Jiang Y, Jin H, Wang D, Liu M, Chen H, Fang L. Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-β production by interfering with the RIG-I signaling pathway. Mol Immunol. 2008, 45(10):2839-2846.
13.Jiang Y, Fang L, Xiao S, Li B, Pan Y, Luo R, Chen H. A suicidal DNA vaccine co-expressing two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus antigens induce protective responses. Biotechnol Lett. 2009, 31(4):509-518.
14.Li B, Xiao S, Wang Y, Xu S, Jiang Y, Chen H, Fang L. Immunogenicity of the highly pathogenic porcine reproductive and respiratory syndrome virus GP5 protein encoded by a synthetic ORF5 gene. Vaccine. 2009, 27(13): 1957-1963.
15.Pan Y, Zhao Q, Fang L, Luo R, Chen H, Xiao S. Efficient gene delivery into mammalian cells by recombinant baculovirus containing a hybrid cytomegalovirus promoter/Semeliki Forest virus replicon. J Gene Med. 2009, 11(11):1030-1038.
16.Wu Q, Fang L, Wu X, Li B, Luo R, Yu Z, Jin M, Chen H, Xiao S. A pseudotype baculovirus-mediated vaccine confers protective immunity against lethal challenge with H5N1 avian influenza virus in mice and chickens. Mol Immunol. 2009, 46(11-12):2210-2217.
17.Huang Q, Yao Q, Fan H, Xiao S, Si Y, Chen H. Development of a vaccine vector based on a subgenomic replicon of porcine reproductive and respiratory syndrome virus. J Virol Methods. 2009 Sep;160(1-2):22-8.
18.Li B, Fang L, Xu Z, Liu S, Gao J, Jiang Y, Chen H, Xiao S. Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome viruses. Emerg Infect Dis. 2009, 15(12):2032-2035.
19.Wang D, Fang L, Luo R, Ye R, Fang Y, Xie L, Chen H, Xiao S. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels. Biochem Biophys Res Commun. 2010, 399(1):72-78.
20.Li B, Fang L, Liu S, Zhao F, Jiang Y, Chen H, Xiao S. The genomic diversity of Chinese porcine reproductive and respiratory syndrome virus isolates from 1996 to 2009. Vet Microbiol. 2010, 10.1016/j.vetmic.1010.05.011.
21.Jiang Y, Fang L, Luo R, Xiao S, Chen H. N-acetylpenicillamine inhibits the replication of porcine reproductive and respiratory syndrome virus in vitro.Vet Res Commun. 2010, 34(7):607-617.
22.Liu W, Fang L, Li S, Li Q, Zhou Z, Feng Z, Luo R, Shao G, Wang L, Chen H, Xiao S. Complete genome sequence of Mycoplasma hyorhinis strain HUB-1. J. Bacteriol. 2010, 192(21): 5844-5845
23.Pan Y, Fang L, Fan H, Luo R, Zhao Q, Chen H, Xiao S. Antitumor effects of a recombinant pseudotype baculovirus expressing Apoptin in vitro and in vivo. Int J Cancer. 2010, 126(11): 2741-2751.
24.Xie L, Liu M, Fang L, Cai K, Wang D, Chen H, Xiao S. Molecular cloning and functional characterization of porcine stimulator of interferon genes (STING). Dev Comp Immunol. 2010, 34(8):847-854.
25.Xie L, Fang L, Wang D, Luo R, Cai K, Chen H, Xiao S. Molecular cloning and functional characterization of porcine DNA-dependent activator of IFN-regulatory factors (DAI). Dev Comp Immunol. 2010, 34(3):293-299.
26.Xu Z, Chang X, Xiao S, Chen H, Zhou R. Evidence for the adaptive evolution of ORF5 gene of Porcine reproductive and respiratory syndrome virus isolated in China. Acta Virol. 2010, 54(4):281-285.
27.Wang Y, Luo R, Fang L, Wang D, Bi J, Chen H, Xiao S. Porcine reproductive and respiratory syndrome virus (PRRSV) infection activates chemokine RANTES in MARC-145 cells. Mol Immunol. 2011, 48(4): 586-591
28.Liu W, Feng Z, Fang L, Zhou Z, Li Q, Li S, Luo R, Wang L, Chen H, Shao G, Xiao S. Complete Genome Sequence of Mycoplasma hyopneumoniae Strain 168. J. Bacteriol. 2011, 193(4): 1016-1017.
29.Wang D, Fang L, Li P, Chen Q, Luo R, Chen H, Xiao S. Molecular cloning of the porcine RANTES promoter: functional characterization of dsDNA/dsRNA response elements in PK-15 cells. Dev Comp Immunol. 2011, 35(3): 345-351.
30.Wang D, Fang L, Zhao F, Luo R, Chen H, Xiao S. Molecular cloning, expression and antiviral activity of porcine interleukin-29 (poIL-29). Dev Comp Immunol. 2011, 35(3): 378-784.
31.Zeng S, Wang D, Fang L, Ma J, Song T, Zhang R, Chen H, Xiao S. Complete coding sequences and phylogenetic analysis of porcine bocavirus (PBoV). J Gen Virol. 2011, 92(4): 784-788.
32.Luo R, Fang L, Jiang Y, Jin H, Wang Y, Wang D, Chen H, Xiao S. Activation of NF-κB by necleocapsid protein of the Porcine reproductive and respiratory syndrome virus (PRRSV). Virus Genes. 2011, 42(1):76-81.
33.Liu M, Tan C, Fang L, Xiao S, Chen H. Microarray analyses of THP-1 cells infected with Streptococcus suis serotype 2. Vet Microbiol. 2011, 150(1-2): 753-758.
34.Wang D, Fang L, Li P, Sun L, Fan J, Zhang Q, Luo R, Liu X, Li K, Chen H, Chen Z, Xiao S. The leader proteinase of foot-and-mouth disease virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase. J. Virol. 2011, 85(8): 3758-3766.
35.Huang H, Xiao S, Qin J, Jiang Y, Yang S, Li T, Gao Y, Li Z, Li T, Su X, Ruan Y, Xu F, Wang H, Chen H, Xia X. Construction and immunogenicity of a recombinant pseudotype baculovirus expressing the glycoprotein of rabies virus in mice. Arch Virol. 2011, 156(5):753-758.
36.Xu Z, Xiao S, Xu P, Xie T, Cao L, Wang D, Luo R, Zhong Y, Chen H, Fang L. miR-365, a novel negative regulator of IL-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB. J Biol Chem. 2011, 286(24):21401-21412.
37.Wang D, Fang L, Bi J, Chen Q, Cao L, Luo R, Chen H, Xiao S. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription in PK-15 cells. Virus Genes. 2011,42(3): 388-393
38.Liu M, Fang L, Tan C, Long T, Chen H, Xiao S. Understanding Streptococcus suis serotype 2 infection in pigs through a transcriptional approach. BMC Genomics. 2011, 12(1):253
39.Li B, Fang L, Guo X, Gao J, Song T, Bi J, He K, Chen H, Xiao S. Epidemiology and evolutionary characteristics of the porcine reproductive and respiratory syndrome virus in China between 2006 and 2010. J Clin Microbiol. 2011, 49(9): 3175-3183.
40.Wang D, Fang L, Liu L, Zhong H, Chen Q, Luo R, Liu X, Zhang Z, Chen H, Xiao S. Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-λ1 pathway. Mol Immunol. 2011, 49(1-2): 407-412.
41.Fang Y, Fang L, Wang Y, Lei Y, Luo R, Wang D, Chen H, Xiao S. Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation. Virol J. 2012, 9: 83.
42.Song T, Fang L, Zeng S, Li B, Chen H, Xiao S. Complete genome sequence of porcine reproductive and respiratory syndrome virus isolated from piglet stool sample. J Virol. 2012, 86(7):4040-4041.
43.Liu W, Fang L, Li M, Li S, Guo S, Luo R, Feng Z, Li B, Zhou Z, Shao G, Chen H, Xiao S. Comparative genomics of Mycoplasma: analysis of conserved essential genes and diversity of the pan-genome. PLoS One. 2012, 7(4):e35698.
44.Cao J, Li B, Fang L, Chen H, Xiao S. Pathogenesis on nonsuppurative encephalitis caused by highly pathogenic porcine reproductive and respiratory syndrome virus). J Vet Diagn Invest. 2012, 24(4):767-771.
45.Lin Y, Xiao S, Zeng Y, Song T, Zeng S, Chen H, Fang L. Complete Genome Sequence of Porcine Kobuvirus Strain W

科研項目

1. 31730095豬δ冠狀病毒輔助蛋白拮抗I型幹擾素的機制及其對緻病性的影響 2018.01
2. 豬δ冠狀病毒滅活疫苗（CHN-HN-2014株）聯合開發協議書 2017.09
3. 豬圓環病毒2型、副豬嗜血杆菌二聯亞單位疫苗 2017.07
4. 技術開發咨詢服務合同 2016.12
5. 農業部農業科研傑出人才及其創新團隊 2016.01
6. 創新人才推進計劃中青年科技創新領軍人才 2016.01
7. 武漢市黃鶴英才計劃（科技領域） 2015.01
8. 宿主抗豬繁殖與呼吸綜合征病毒感染的保護性免疫機制 2015.01
9. 抗仔豬腹瀉卵黃抗體蛋白聯合開發協議 2014.01
10. 豬繁殖與呼吸綜合征病毒調控炎症反應的分子機制 2014.01
11. 動物病毒與宿主免疫系統的相互作用研究及新型疫苗創制 2014.01
12. 豬繁殖與呼吸綜合征病毒調控炎症反應的分子機制01 2014.01
13. 豬繁殖與呼吸綜合征病毒感染激活IL-1β的分子機制及其生物學意義 2013.01
14. 動物病毒與宿主免疫系統的相互作用 2013.01 15. 動物傳染病學 2013.01 16. 豬肺炎支原體全基因組ORFs的克隆、表達及診斷标識的挖掘 2012.01 17. 豬繁殖與呼吸綜合征病毒感染激活IL-10的分子機制研究 2009.01

個人簡介

教育經曆

工作經曆

研究領域

科研成果

科研項目

主要獎勵